Anti-Hu CD79a Purified Monoclonal Antibody

Product Name

Anti-Hu CD79a Purified Monoclonal Antibody

View all CD79A Antibodies

SKU/Catalog Number

M01047-4

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Hu CD79a Purified Monoclonal Antibody (Catalog# M01047-4). Tested in Flow Cytometry, IP, WB, IHC-P application(s). This antibody reacts with Dog, Chicken, Rabbit, Guinea pig, Horse, Cow, Mouse, Rat, Pig, Primate, Human.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-Hu CD79a Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01047-4)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

HM47

Isotype

Mouse IgG1 kappa

Immunogen

Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a. The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M01047-4 is reactive to CD79A in Chicken, Cow, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Primate, Horse

Applications

M01047-4 is guaranteed for Flow Cytometry, IP, IHC-P, WB Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

25.038kDa

Background of CD79A

CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow cytometry: 1-4 μg/ml, intracellular staining.
Western blotting: 1-2 μg/ml.

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For CD79A (Source: Uniprot.org, NCBI)

Alternative Names

CD79A antigen (immunoglobulin-associated alpha); CD79a antigen; CD79a molecule, immunoglobulin-associated alpha; CD79A; IGAB-cell antigen receptor complex-associated protein alpha chain; ig-alpha; MB-1 membrane glycoprotein; MB1; MB-1; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein CD79A IGA, MB-1 CD79a molecule B-cell antigen receptor complex-associated protein alpha chain|CD79a antigen (immunoglobulin-associated alpha)|CD79a molecule, immunoglobulin-associated alpha|MB-1 membrane glycoprotein|ig-alpha|membrane-bound immunoglobulin-associated protein|surface IgM-associated protein

For more info on CD79A, check out the CD79A Infographic

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In this infographic, you will see the following information for CD79A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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